Which combination of conditions increases risk of skin breakdown?

• A. Diabetes, poor circulation, immune disorders
• B. Hypertension, obesity, high cholesterol
• C. Asthma, allergies
• D. Exercise, hydration, vitamins

Answer: (A)

Skin breakdown risk climbs when factors directly affecting skin healing, sensation, and tissue perfusion are present together. Diabetes can impair wound healing and immune function while also causing neuropathy, which dulls sensation and delays noticing pressure or minor injuries. Poor circulation means less blood flow and oxygen to tissues, making skin more vulnerable under pressure and slowing repair. Immune disorders weaken the body's ability to fight infection and mount an effective healing response, allowing wounds to develop and persist.

Because these three conditions combine to undermine sensation, blood supply, and immune defense, they create the strongest setup for skin breakdown. Other choices don’t stack these direct risks as clearly: hypertension and high cholesterol influence vascular health but don’t centralize healing and sensation; obesity adds load and moisture risk but isn’t as directly tied to impaired healing or sensation; asthma/allergies don’t primarily affect skin integrity. Exercise, hydration, and vitamins, on the other hand, support skin health and healing.